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  1. Pathogenesis Connective Tissue and Joint Diseases red if traumatic CONNECTIvE TISSUE aND JOINT DISEaSES l TABLE Major Arthritides Osteoarthritis Rheumatoid Arthritis Gouty Arthritis Onset Insidious Insidious Sudden Common locations Weightbearing joints knees hips lumbarcervical Hands PIP MCP wrists ankles knees Great toe ankles knees elbows spine hands Presence of inflammation No Yes Yes Radiographic changes Narrowed joint space osteo phytes subchondral sclero sis subchondral cysts Narrowed joint space bony erosions Punchedout erosions with overhanging rim of cortical bone Laboratory findings None Elevated ESR RF anemia Crystals Other features No systemic findings Bouchards nodes and Heberdens nodes in hands Systemic findings extraarticular manifesta tions common Tophi Nephrolithiasis Ulnar deviation swanneck and boutonniere deformity a. overnight cialis delivery

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